Hande Ozdinler, PhD, one of the lead researchers at our Les Turner ALS Center at Northwestern Medicine, and her collaborators just published new findings in the journal Acta Neuropathologica.
From Dr. Ozdinler, “We for the first time discovered the cellular defects that occur in the upper motor neurons with respect to TDP-43 pathology. TDP-43 pathology is one of the most common pathologies in ALS, present in about 95% of all ALS cases.
We did not know what happened in the upper motor neurons and now we discovered that their mitochondria, endoplasmic reticulum and nuclear membrane transport are affected very early in the disease.”
We are thankful for many things this Thanksgiving, especially the extraordinary work coming out of our Les Turner ALS Center at Northwestern Medicine. This new discovery by Dr. Ozdinler gives us continued hope for a world free of ALS.