Below you'll find a list of all posts that have been tagged as “clinical research”
Study links TDP‑43 pathology to inflammation, disease progression and survival across ALS subtypes. Study used cutting-edge techniques to analyze blood, spinal cord samples from hundreds of patients Immune signatures differ by ALS type (genetic or non-genetic), disease stage, speed of …
As director of the clinical research program at the Les Turner ALS Center at Northwestern Medicine, Senda Ajroud-Driss has seen her share of potential ALS therapies. Though many drugs have not made it past clinical trials, recent advances have given …
To understand neurodegenerative diseases like ALS, researchers are looking beyond individual neurons and examining tiny bridges that connect neurons to other neurons. These bridges, called tunneling nanotubes (TNTs), shuttle molecules and proteins between cells, including small structures with specific functions …
One distinct hallmark of ALS is the dysfunction of a tiny protein called TDP-43. This protein normally lives within a cell’s nucleus, but in the case of ALS, it becomes dysfunctional, migrates out, and aggregates into the cell’s cytoplasm. The …
In the search for the underlying mechanisms of ALS, researchers are examining the role of even the tiniest parts of neuron cells. In fact, studies have shown that in ALS patients, microtubules—which are the major component of the cell cytoskeleton …
Together with the Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital, the Les Turner ALS Center at Northwestern Medicine is thrilled to announce the launch of the Acceleration Centers of Enrollment (ACE) initiative. The ACE initiative …
As many as 2% of all ALS cases have been linked to mutations in the gene NEK1, making it one of the top-known causes of the disease. But it wasn’t known how the mutated gene disrupts the function of the …
New results from the Phase 3 clinical trial of tofersen, a drug in development by Biogen, have shown promise in treatment of superoxide dismutase 1 (SOD1) amyotrophic lateral sclerosis (ALS). According to the 12-month data, earlier initiation of treatment with …
As connecting fibers between motor neurons, axons help deliver vital messages between the brain and the spinal cord. For people living with ALS, deteriorating axons cause that connection to break, contributing to paralysis and death. Early research on NU-9, an …
This story has been updated with a link to the informational webinar about the new medication. The U.S. Food and Drug Administration has approved RADICAVA ORS®, an oral form of edaravone that reports the same efficacy as RADICAVA® for intravenous infusion. …
