One distinct hallmark of ALS is the dysfunction of a tiny protein called TDP-43. This protein normally lives within a cell’s nucleus, but in the case of ALS, it becomes dysfunctional, migrates out, and aggregates into the cell’s cytoplasm. The …
Discovering how motor neurons break down in ALS
In the search for the underlying mechanisms of ALS, researchers are examining the role of even the tiniest parts of neuron cells. In fact, studies have shown that in ALS patients, microtubules—which are the major component of the cell cytoskeleton …
A new clue to ALS and FTD: Faulty protein disrupts brain’s ‘brake’ system
Findings point to promising drug that restores neuron balance and may slow disease progression A new Northwestern University study using patient nervous tissue and lab-grown human neurons has uncovered how a key disease protein, TDP-43, drives overactive nerve cells in …
Les Turner ALS Center at Northwestern Medicine and Sean M. Healey & AMG Center for ALS Establish Acceleration Centers of Enrollment Initiative
Together with the Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital, the Les Turner ALS Center at Northwestern Medicine is thrilled to announce the launch of the Acceleration Centers of Enrollment (ACE) initiative. The ACE initiative …
‘New’ ALS gene destabilizes neuron’s structure and chokes off its nucleus
As many as 2% of all ALS cases have been linked to mutations in the gene NEK1, making it one of the top-known causes of the disease. But it wasn’t known how the mutated gene disrupts the function of the …
July 2023 Foundation eNews
Future ALS Walk for Life Captains in the Making Our ALS Walk for Life team captains play a vital role in the event’s success. They tirelessly recruit teammates and raise funds through various channels, including emails, phone calls, and social …
June 2023 Foundation eNews
22nd Annual ALS Walk for Life Kickoff We are thrilled to announce the upcoming 2023 ALS Walk for Life, the largest ALS gathering in the Midwest! This highly anticipated event brings together thousands of individuals, families, and teams who share a common …
May 2023 Foundation eNews
ALS Awareness Month: Supporting Our Veterans ALS Awareness Month is just about to wrap up. Over the past few weeks we’ve been highlighting different themes, ranging from information about ALS itself to shining a spotlight on members of our community. This …
May 2023 Foundation eNews
ALS Awareness Month: Celebrating nurses As ALS Awareness Month continues, we’re taking the opportunity to celebrate the nurses who make an enormous difference for people living with ALS. We can’t possibly thank nurses enough for the care they provide. If you feel …
May 2023 Foundation eNews
ALS Awareness Month: Take action! May is ALS Awareness Month, a terrific opportunity to share your commitment to ALS care and research with friends and colleagues. All month, we’ll be sharing ideas to help you make an impact and highlighting people …
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